Cell lines by gene mutation tumor cell lines become more powerful tools for cancer research and drug discovery when the genetic abnormalities that drive their phenotype are known.
P53 mutation cancer cell lines.
One strain lncap gw had a mutation in one of two alleles at position 273 arg.
Cell lines with a controversial p53 status.
Knowledgebase and statistical tools for the analysis of tp53 gene mutations in human cancers.
Esophageal cancer cell lines.
Since then a large number of publications have demonstrated many gofs in numerous cell lines with a variety of p53 mutations summarized in table 1 the gof acquired by mutant p53 is further supported by the finding that patients carrying a tp53 missense mutation leading to expression of a.
Colorectal cancer cell lines.
Epub 2008 may 11.
Ht 29 caco 2 and sw480 contain mutated p53 were used as the panels in this study to.
Brain cancer cell lines.
Our laboratory has two separate culture lines of the lncap human prostate cancer cells.
The p53 mutations in cell lines compendium the current version includes 2 000 and 500 cell lines with mutant tp53 and wild type tp53 respectively.
Tcp 2020 is composed of six select cell lines derived from colon cancer.
This panel combines wild type p53 cell lines with mutant p53 cell lines that carry hotspot mutations in one of the following codons.
When the introduction of mutant p53 into p53 null cells was shown to give rise to a new phenotype.
1 karolinska institute department of oncology pathology cancer center karolinska cck stockholm.
Hct 116 cells contain wild type p53.
Several fundamental features of wild type and mutant proteins and their modifications are reviewed as well as animal models and clinical aspects such as recommendations for patient care.
The hanbook of p53 mutation in cell lines.
Bladder cancer cell lines.
The id cards include cell line data such as cancer type and atcc number when available as well as some specific information on potential misidentifications changes of identity or shared origins.
A special issue of human mutation has been released.
P53 gene structure and chromosome 17p alleles were studied in the three human prostate cancer cell lines lncap du 145 and pc 3.
P53 mutations in cell lines.
Analysis of p53 mutation status in human cancer cell lines.
Berglind h 1 pawitan y kato s ishioka c soussi t.
The colon cancer p53 hotspot mutation cell panel atcc no.
175 245 248 or 273.
The tp53 gene network in the post genomic era.
Human colon cancer cell lines with varied molecular characteristics eg.
The nci 60 panel.
Breast cancer cell lines.
